Novel bio-inspired 3D porous scaffold intended for bone-tissue engineering: Design and in silico characterisation of histomorphometric, mechanical and mass-transport properties

The design of novel biomimetic bone tissue scaffolds (BTS) using computer aided (CAD) technology is challenging additive manufacturing technologies. At the microstructure level, BTS should mimic histomorphometry and assure optimum mass transport mechanical properties. In this study, a has been designed, by parametric variational CAD method, to model bio-inspired interconnected porous structure. (elastic modulus) fluid (permeability) properties have computed compared other implicit surfaces modelling scaffolds. results showed that new could be tuned during stage match trabecular bone. Those with porosities between 0.7 0.9 highly smooth curvatures were most appropriates. BTS, once appropriately made/manufactured 3D printing an internal mimicking local selected volumes interest, for example, those coming from tomography medical images.